![]() Nevertheless, it cannot say confidentially that uses of probiotics are universally recommended in IBS patients because of many factors, including subtypes of IBS (IBS-D, IBS-C, and IBS-M), heterogeneity, and different outcomes due to the use of various stains, dosing of probiotics, and therapy duration although in practice, NICE in the United Kingdom recommends that the use of probiotics according to manufacturer's orders at least for 4 months would be beneficial for IBS patients if any adverse effect be in control and therapeutic efficacy be monitored carefully. Many studies have shown that uses of probiotics were useful in IBS symptoms such as abdominal pain. They have the beneficial effect on gut microenvironment by enhancing the defense through production of strong barrier in intestinal, making better mobility, releasing bacteriocidins, the effect on immune system, which leads to producing anti-inflammatory agents and immune regulation, and preventing of pathogens for adhesion to the gut epithelium. Probiotics are live microorganisms using in dietary as supplemental products. Some measures can be done to reach balance of the gut microbiome such as using of prebiotics, antibiotics, specific diets, probiotics, and microbial transplantation for restoring balance in bacterial flora. Microbiome analyses have revealed dysbiosis however, the microbial pattern was not consistent in patients with IBS. There are a variety of heterogeneous abnormalities seen in IBS patients, and also, the diversity of bacterial species was reported to be reduced during disease phase. Everybody has a specific microbiota due to his diet, infection and antibiotic use, mode of birth, age, and kind of feeding. It has been reported that microbiota has a noticeable role in the pathogenesis of IBS. Some factors such as psychological aspects,, genetics, and food are known to have an antecedent role in IBS. ![]() Many factors are in association with IBS such as unsuitable quality of life, having high mental stress as well as many pathophysiological factors, which lead to the imposition of considerable health costs on different societies. Females are more at risk of affection than men by 2:1 in the western countries. There is not any specific age conflicted by the disorder, but the most common age of affection is observed in young adult. Irritable bowel syndrome (IBS) is a gastrointestinal (GI) tract disorder with high worldwide incidence. Effect of Probiotic Administration Immediately and 1 Month after Colonoscopy in Diarrhea-predominant Irritable Bowel Syndrome Patients. How to cite this URL: Khodadoostan M, Shavakhi A, Sherafat Z, Shavakhi A. ![]() How to cite this article: Khodadoostan M, Shavakhi A, Sherafat Z, Shavakhi A. Keywords: Clinical trial, irritable bowel syndrome, probiotics, symptoms of disease Furthermore, it can be said that reductions in symptoms and pain in the two treatment groups were not significantly different, but after 6 months of treatment, the effect of probiotics in patients who immediately use it after colonoscopy was more visible and more stable. Conclusion: According to our results, the use of probiotics had the beneficial effect on IBS symptoms. Results: The mean reduction in abdominal pain was 3.05 ± 1.21, 3.86 ± 0.94, and 3.82 ± 0.63 in the control group, immediate probiotic users, and 1 month after colonoscopy, respectively ( P 0.05). All the patients were interviewed for having common IBS symptoms (stool consistency and frequency, gas, abdominal pain, and flatulence) at baseline, 3 rd month of follow-up, and 6 th month of follow-up. Materials and Methods: Our patients were divided among three groups, including immediate probiotic users, start use of probiotics 1 month after colonoscopy, and placebo group. Various studies have demonstrated that the use of probiotics can reduce the overall symptom of IBS, and thus, our aim was to evaluate the efficacy of probiotic products in the reduction of IBS syndrome after colonoscopy. Background: Irritable bowel syndrome (IBS) is one of the most common disorders among young adults.
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